The more willing you are to travel at a moment's notice, the more opportunities you can access. Day jobs will limit travel, so will mortgages and car payments. Photojournalist Lynsey Addario recently wrote about being 7 months pregnant while on assignment in Gaza. I deeply admire her bravery and commitment to her work, but I imagine many photographers aren't willing to make such compromises. Consider your lifestyle, and how much time you're willing to spend away from home. As for myself, I'm a long-term digital nomad traveling with a suitcase and a backpack and an open mind. Being available and flexible has made a monumental difference to my career.
Make use of people to give your images life and scale. If the facade of a particular building appeals to you, the picture may be that much better if you show people walking in front of it. They will give it scale and also let viewers know what sorts of people live there, how they dress, and the like. An outdoor café may be more interesting crowded with people than empty.